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Guidance document for testing the pathogenicity and toxicity of new microbial substances to aquatic and terrestrial organisms: En49-7/1-44-2016E-PDF

“The intent of this document is to provide guidance on preparing for and conducting single-species tests to measure and evaluate the pathogenicity and/or toxicity of new microbial substances to aquatic and terrestrial organisms. It focuses on the information requirements with respect to laboratory tests for measuring the potential ecological effects of new microbial substances on the following six categories of test (host) organisms, that might be required by Environment and Climate Change Canada as part of the New Substances Notification (NSN) Regulations under the Canadian Environmental Protection Act, 1999: (1) an aquatic plant; (2) an aquatic invertebrate; (3) an aquatic vertebrate; (4) a terrestrial plant; (5) a terrestrial invertebrate; and (6) a terrestrial vertebrate. The guidance herein is intended for notifiers, environmental consultants, study directors, and principal investigators. It will assist in the selection of an appropriate series of biological test methods for measuring the pathogenicity and/or toxicity of new microbial substances, as well as in the planning, execution, and reporting phases associated with each test. Changes introduced in this second edition of the guidance have primarily come from microbial substance testing experience in Environment and Climate Change Canada research laboratories and improvements in test methodologies over the past decade”--Abstract, p. ii.

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Department/Agency Environment and Climate Change Canada.
Title Guidance document for testing the pathogenicity and toxicity of new microbial substances to aquatic and terrestrial organisms
Series Title Report ;
Publication Type Monograph
Language [English]
Other Language Editions [French]
Format Electronic
Electronic Document

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Note Issued also in French under title: Guide des essais de pathogénicité et de toxicité de nouvelles substances microbiennes pour les organismes aquatiques et terrestres. Co-authors: D. McLeay ... et al; 2nd edition prepared by Ryan Hennessy. Cf. Acknowledgements.
Date c2017.
Number of Pages xxxii, 176 p.
ISBN 978-0-660-06864-0
Catalogue Number
  • En49-7/1-44-2016E-PDF
Edition 2nd ed., December 2016.
Subject Terms Microorganisms, Bioassay, Toxicology, Methodology, Standards