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| 02700cam 2200445zi 4500 |
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| 001 | 9.871273 |
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| 003 | CaOODSP |
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| 005 | 20221107163337 |
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| 006 | m o d f |
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| 007 | cr cn||||||||| |
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| 008 | 190408t20182018onca ob f000 0 eng d |
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| 040 | |aCaOODSP|beng|erda|cCaOODSP |
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| 041 | |aeng|bfre |
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| 043 | |an-cn--- |
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| 086 | 1 |aD68-2/189-2018E-PDF |
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| 100 | 1 |aStratilo, Chad W., |eauthor. |
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| 245 | 10|aIdentification of a novel virulence factor of Burkholderia pseudomallei and B. mallei, a protective vaccine antigen against melioidosis / |cChad W. Stratilo, Rick Swayze, Scott Jager, DRDC - Suffield Research Centre. |
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| 264 | 1|aMedicine Hat, Alberta : |bDefence Research and Development Canada = Recherche et développement pour la défense Canada, |c2018. |
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| 264 | 4|c©2018 |
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| 300 | |a1 online resource (vi, 19 pages, 2 unnumbered pages) : |billustrations. |
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| 336 | |atext|btxt|2rdacontent |
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| 337 | |acomputer|bc|2rdamedia |
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| 338 | |aonline resource|bcr|2rdacarrier |
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| 490 | 1 |aScientific report ; |vDRDC-RDDC-2018-R189 |
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| 500 | |aCover title. |
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| 500 | |a"Can unclassified." |
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| 500 | |a"October 2018." |
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| 504 | |aIncludes bibliographical references. |
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| 520 | 3 |a"Burkholderia pseudomallei is the causative agent of melioidosis, a severe systemic, potentially life-threatening disease with many possible manifestations in humans. This pathogen expresses a large number of virulence factors, with many found on islands of pathogenesis. Significant efforts have been invested into vaccine development; however none have offered complete protection. A unique and conserved protein of B. pseudomallei and B. mallei has been identified as the exoprotein of a two-partner secretion pathway. This exoprotein, when expressed in a recombinant form effected the formation of actin tails in macrophage cell culture, suggesting a role in intracellular spread and a possible role in virulence. A truncated recombinant form of this protein conferred protection against B. pseudomallei and B. mallei challenge in mice when used as a vaccine candidate"--Abstract, page i. |
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| 546 | |aIncludes abstract in French. |
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| 653 | 10|aBurkholderia pseudomallei |
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| 653 | 10|aBurkholderia mallei |
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| 653 | 10|aMelioidosis |
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| 653 | 10|aRecombinant proteins |
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| 692 | 07|2gccst|aImmunization |
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| 700 | 1 |aSwayze, Rick, |eauthor. |
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| 700 | 1 |aJager, Scott, |eauthor. |
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| 710 | 1 |aCanada. |bDefence R&D Canada. |bSuffield Research Centre. |
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| 830 | #0|aScientific report (Defence R&D Canada)|vDRDC-RDDC-2018-R189.|w(CaOODSP)9.802305 |
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| 856 | 40|qPDF|s728 KB|uhttps://publications.gc.ca/collections/collection_2019/rddc-drdc/D68-2-189-2018-eng.pdf |
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