Identification of a novel virulence factor of Burkholderia pseudomallei and B. mallei, a protective vaccine antigen against melioidosis / Chad W. Stratilo, Rick Swayze, Scott Jager, DRDC - Suffield Research...: D68-2/189-2018E-PDF
"Burkholderia pseudomallei is the causative agent of melioidosis, a severe systemic, potentially life-threatening disease with many possible manifestations in humans. This pathogen expresses a large number of virulence factors, with many found on islands of pathogenesis. Significant efforts have been invested into vaccine development; however none have offered complete protection. A unique and conserved protein of B. pseudomallei and B. mallei has been identified as the exoprotein of a two-partner secretion pathway. This exoprotein, when expressed in a recombinant form effected the formation of actin tails in macrophage cell culture, suggesting a role in intracellular spread and a possible role in virulence. A truncated recombinant form of this protein conferred protection against B. pseudomallei and B. mallei challenge in mice when used as a vaccine candidate"--Abstract, page i.
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|Department/Agency||Canada. Defence R&D Canada. Suffield Research Centre.|
|Title||Identification of a novel virulence factor of Burkholderia pseudomallei and B. mallei, a protective vaccine antigen against melioidosis / Chad W. Stratilo, Rick Swayze, Scott Jager, DRDC - Suffield Research Centre.|
|Series title||Scientific report ; DRDC-RDDC-2018-R189|
|Publication type||Series - View Master Record|
|Note(s)|| Cover title. |
Includes bibliographical references.
Includes abstract in French.
|Publishing information|| Medicine Hat, Alberta : Defence Research and Development Canada = Recherche et développement pour la défense Canada, 2018. |
|Author / Contributor|| Stratilo, Chad W.,author. |
|Description||1 online resource (vi, 19 pages, 2 unnumbered pages) : illustrations.|
|Catalogue number|| |
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