Identification of a novel virulence factor of Burkholderia pseudomallei and B. mallei, a protective vaccine antigen against melioidosis / Chad W. Stratilo, Rick Swayze, Scott Jager, DRDC - Suffield Research...: D68-2/189-2018E-PDF

"Burkholderia pseudomallei is the causative agent of melioidosis, a severe systemic, potentially life-threatening disease with many possible manifestations in humans. This pathogen expresses a large number of virulence factors, with many found on islands of pathogenesis. Significant efforts have been invested into vaccine development; however none have offered complete protection. A unique and conserved protein of B. pseudomallei and B. mallei has been identified as the exoprotein of a two-partner secretion pathway. This exoprotein, when expressed in a recombinant form effected the formation of actin tails in macrophage cell culture, suggesting a role in intracellular spread and a possible role in virulence. A truncated recombinant form of this protein conferred protection against B. pseudomallei and B. mallei challenge in mice when used as a vaccine candidate"--Abstract, page i.

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Publication information
Department/Agency Canada. Defence R&D Canada. Suffield Research Centre.
Title Identification of a novel virulence factor of Burkholderia pseudomallei and B. mallei, a protective vaccine antigen against melioidosis / Chad W. Stratilo, Rick Swayze, Scott Jager, DRDC - Suffield Research Centre.
Series title Scientific report ; DRDC-RDDC-2018-R189
Publication type Series - View Master Record
Language [English]
Format Electronic
Electronic document
Note(s) Cover title.
"Can unclassified."
"October 2018."
Includes bibliographical references.
Includes abstract in French.
Publishing information Medicine Hat, Alberta : Defence Research and Development Canada = Recherche et développement pour la défense Canada, 2018.
©2018
Author / Contributor Stratilo, Chad W.,author.
Swayze, Rick,author.
Jager, Scott,author.
Description 1 online resource (vi, 19 pages, 2 unnumbered pages) : illustrations.
Catalogue number
  • D68-2/189-2018E-PDF
Subject terms Immunization
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