An evaluation of the potential use of mixed function oxygenase induction to define virtual elimination of PCDDs and PCDFs / Mark Servos ... [et al.]. : En13-5/97-65E-PDF

"The definition of virtual elimination has created considerable debate. The traditional approach has been to use the chemically defined detection limits that are determined using the best available methodologies. This leads to the problem that the target for virtual elimination of a contaminant is dependent on the ever increasing improvements in analytical techniques. Although a chemical can be eliminated below some extremely sensitive chemical detection limit it might not exert biological effects at that level. The detection limits may also be much lower than background in the environment. Conversely biological responses may result from trace levels of a compound that can not be detected chemically. An alternative to the chemical endpoint may be an effects-based definition of virtual elimination. This document is a discussion of the possible application of a specific biological response (mixed function oxygenase activity) to define virtual elimination of polychlorinated dioxins and furans. In this overview, several possible approaches are explored and the advantages and limitations of each are discussed"--Management perspective.

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