00000nam 2200000za 4500 9.821157 CaOODSP 20240219183434 cr ||||||||||| 160715s2012 onc|||||o f000 0 eng d CaOODSP eng eng fre n-cn--- D68-4/175-2012E-PDF Secreted cytokines as possible biomarkers of exposure to ionizing radiation [electronic resource] / by Hillary Boulay Greene ... [et al.]. [Ottawa] : Defence Research and Development Canada, c2012. xi, 30 p. : figures, graphs, tables. Technical report ; 2012-175 "September 2012." Includes bibliographical references. The quest for reliable and unique biomarkers of radiation exposure is an ongoing challenge in the field of radiation biology. Once identified they will provide an invaluable tool for both clinicians wanting to assess therapeutic outcomes of patients as well as first responders and medical personnel needing to rapidly triage populations of potentially exposed people following an radiation/nuclear (RN) event. It has been reported that there is an acute inflammatory response following exposure to ionizing radiation. We hypothesize that this is initiated in part by cytokines secreted from various cell types within the body and that these secreted cytokines may serve as biomarkers for exposure. The various studies described in this report examine the cytokine response following radiation exposure from a single cell line model through to animal studies. gccst Technical reports Ionizing radiation Biomarkers Cytokines Greene, Hillary Boulay. Defence R&D Canada. Technical report (Defence R&D Canada) 2012-175 (CaOODSP)9.820558 PDF 931 KB https://publications.gc.ca/collections/collection_2016/rddc-drdc/D68-4-175-2012-eng.pdf