000 01995nam  2200313za 4500
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008160715s2012    onc|||||o    f000 0 eng d
040 |aCaOODSP|beng
041 |aeng|bfre
043 |an-cn---
0861 |aD68-4/175-2012E-PDF
24500|aSecreted cytokines as possible biomarkers of exposure to ionizing radiation |h[electronic resource] / |cby Hillary Boulay Greene ... [et al.].
260 |a[Ottawa] : |bDefence Research and Development Canada, |cc2012.
300 |axi, 30 p. : |bfigures, graphs, tables.
4901 |aTechnical report ; |v2012-175
500 |a"September 2012."
504 |aIncludes bibliographical references.
520 |aThe quest for reliable and unique biomarkers of radiation exposure is an ongoing challenge in the field of radiation biology. Once identified they will provide an invaluable tool for both clinicians wanting to assess therapeutic outcomes of patients as well as first responders and medical personnel needing to rapidly triage populations of potentially exposed people following an radiation/nuclear (RN) event. It has been reported that there is an acute inflammatory response following exposure to ionizing radiation. We hypothesize that this is initiated in part by cytokines secreted from various cell types within the body and that these secreted cytokines may serve as biomarkers for exposure. The various studies described in this report examine the cytokine response following radiation exposure from a single cell line model through to animal studies.
69207|2gccst|aTechnical reports
693 4|aIonizing radiation
693 4|aBiomarkers
693 4|aCytokines
7001 |aGreene, Hillary Boulay.
7102 |aDefence R&D Canada.
830#0|aTechnical report (Defence R&D Canada)|v2012-175|w(CaOODSP)9.820558
85640|qPDF|s931 KB|uhttps://publications.gc.ca/collections/collection_2016/rddc-drdc/D68-4-175-2012-eng.pdf