Performance characteristics to assess a receptor-ligand biosensor / William E. Lee, Shiliang Wang, Susan J. Rowsell, DRDC – Suffield Research Centre.: D68-2/178-2017E-PDF

"Biosensors represent an important area of technology for biodetection, bioidentification, diagnostics, medical countermeasures, and human performance within the operations of the Canadian Armed Forces (CAF). The development of biological detection, identification, and monitoring (BioDIM) systems is a multi-step process that requires the assessment of candidate biosensor technologies at each step for further technology advancement. The CAF Directorate Chemical Biological Radiological Nuclear Defence (D CBRN D) sponsors research and development of biosensor technology within the DRDC CBRN Defence Program Inform Project. The present report contains an overview of the fundamental concepts associated with the predominant class of biosensors, those based on receptor-ligand interactions. Such biosensors comprise two distinct components, an electronic transducer device and molecular recognition elements (MREs) that together are able to detect particular chemical or biological analyte molecules. In a biosensor technology development project, normally the sponsor directs resources at the electronic transducer component plus hardware of the BioDIM system rather than the MREs. The focus of the report is on the performance characteristics of the transducer plus associated hardware, i.e., the areas where the sponsor would direct resources. This report outlines some performance characteristics of biosensors and provides analysis and guidance for assessing new biosensor technologies. The objective of the report is to provide CAF sponsors with tools and strategies for assessing biosensor development, hence to enhance the return on investment of DND resources"--Abstract, p. i.

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