00000nam 2200000zi 4500 9.871273 CaOODSP 20240220151437 m o d f cr cn||||||||| 190408t20182018onca ob f000 0 eng d CaOODSP eng rda CaOODSP eng fre n-cn--- D68-2/189-2018E-PDF Stratilo, Chad W., author. Identification of a novel virulence factor of Burkholderia pseudomallei and B. mallei, a protective vaccine antigen against melioidosis / Chad W. Stratilo, Rick Swayze, Scott Jager, DRDC - Suffield Research Centre. Medicine Hat, Alberta : Defence Research and Development Canada = Recherche et développement pour la défense Canada, 2018. ©2018 1 online resource (vi, 19 pages, 2 unnumbered pages) : illustrations. text txt rdacontent computer c rdamedia online resource cr rdacarrier Scientific report ; DRDC-RDDC-2018-R189 Cover title. "Can unclassified." "October 2018." Includes bibliographical references. "Burkholderia pseudomallei is the causative agent of melioidosis, a severe systemic, potentially life-threatening disease with many possible manifestations in humans. This pathogen expresses a large number of virulence factors, with many found on islands of pathogenesis. Significant efforts have been invested into vaccine development; however none have offered complete protection. A unique and conserved protein of B. pseudomallei and B. mallei has been identified as the exoprotein of a two-partner secretion pathway. This exoprotein, when expressed in a recombinant form effected the formation of actin tails in macrophage cell culture, suggesting a role in intracellular spread and a possible role in virulence. A truncated recombinant form of this protein conferred protection against B. pseudomallei and B. mallei challenge in mice when used as a vaccine candidate"--Abstract, page i. Includes abstract in French. Burkholderia pseudomallei Burkholderia mallei Melioidosis Recombinant proteins gccst Immunization Swayze, Rick, author. Jager, Scott, author. Defence R&D Canada - Suffield. Scientific report (Defence R&D Canada) DRDC-RDDC-2018-R189. (CaOODSP)9.802305 PDF 728 KB https://publications.gc.ca/collections/collection_2019/rddc-drdc/D68-2-189-2018-eng.pdf