000 02673nam  2200445zi 4500
0019.871273
003CaOODSP
00520240220151437
006m     o  d f      
007cr cn|||||||||
008190408t20182018onca    ob   f000 0 eng d
040 |aCaOODSP|beng|erda|cCaOODSP
041 |aeng|bfre
043 |an-cn---
0861 |aD68-2/189-2018E-PDF
1001 |aStratilo, Chad W., |eauthor.
24510|aIdentification of a novel virulence factor of Burkholderia pseudomallei and B. mallei, a protective vaccine antigen against melioidosis / |cChad W. Stratilo, Rick Swayze, Scott Jager, DRDC - Suffield Research Centre.
264 1|aMedicine Hat, Alberta : |bDefence Research and Development Canada = Recherche et développement pour la défense Canada, |c2018.
264 4|c©2018
300 |a1 online resource (vi, 19 pages, 2 unnumbered pages) : |billustrations.
336 |atext|btxt|2rdacontent
337 |acomputer|bc|2rdamedia
338 |aonline resource|bcr|2rdacarrier
4901 |aScientific report ; |vDRDC-RDDC-2018-R189
500 |aCover title.
500 |a"Can unclassified."
500 |a"October 2018."
504 |aIncludes bibliographical references.
5203 |a"Burkholderia pseudomallei is the causative agent of melioidosis, a severe systemic, potentially life-threatening disease with many possible manifestations in humans. This pathogen expresses a large number of virulence factors, with many found on islands of pathogenesis. Significant efforts have been invested into vaccine development; however none have offered complete protection. A unique and conserved protein of B. pseudomallei and B. mallei has been identified as the exoprotein of a two-partner secretion pathway. This exoprotein, when expressed in a recombinant form effected the formation of actin tails in macrophage cell culture, suggesting a role in intracellular spread and a possible role in virulence. A truncated recombinant form of this protein conferred protection against B. pseudomallei and B. mallei challenge in mice when used as a vaccine candidate"--Abstract, page i.
546 |aIncludes abstract in French.
65310|aBurkholderia pseudomallei
65310|aBurkholderia mallei
65310|aMelioidosis
65310|aRecombinant proteins
69207|2gccst|aImmunization
7001 |aSwayze, Rick, |eauthor.
7001 |aJager, Scott, |eauthor.
7101 |aDefence R&D Canada - Suffield.
830#0|aScientific report (Defence R&D Canada)|vDRDC-RDDC-2018-R189.|w(CaOODSP)9.802305
85640|qPDF|s728 KB|uhttps://publications.gc.ca/collections/collection_2019/rddc-drdc/D68-2-189-2018-eng.pdf