Chemical weapon agent studies in domestic swine : part 5 : comparative bioavailability of different HI-6 salt forms in the domestic pig / prepared by: Kinchyle Enterprises Inc.: D68-3/170-2002E-PDF
"A well-developed anesthetized domestic swine model has been utilized to study the following effect of chemical weapons (CW): 01 - Comparative bioavailability of different HI-6 salt forms in the domestic pig. The bioavailability of the dihydrochloride salt of HI-6a (currently utilized) was compared to that of the dimethanesulfonate salt (HI-6b). The latter is more water-soluble at low temperatures. The salts appear similarly clinically, biochemically or hematologically in the "equivalent" doses administered (HI-6 dihychloride = 500 mg, HI-6 dimethanesulfonate = 633 mg.) A notable exception might be the observation that the combination of pyridostigmine (PYR)/HI-6b increases airway resistance. Timed plasma and urine samples were collected for HPLC analysis"--Abstract, page i.
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| Department/Agency | Defence R&D Canada - Suffield. |
|---|---|
| Title | Chemical weapon agent studies in domestic swine : part 5 : comparative bioavailability of different HI-6 salt forms in the domestic pig / prepared by: Kinchyle Enterprises Inc. |
| Variant title | Comparative bioavailability of different HI-6 salt forms in the domestic pig |
| Series title | Contract report ; DRDC Suffield CR 2002-C170 |
| Publication type | Series - View Master Record |
| Language | [English] |
| Format | Electronic |
| Electronic document | |
| Note(s) | "September 2002." "PWGSC Contract Number: W7702-99-R785." Includes abstract in French. |
| Publishing information | Medicine Hat, Alberta, Canada : Defence Research and Development Canada = Recherche et développement pour la défense Canada, 2002. ©2002 |
| Description | 1 online resource (ii, 37 pages, 2 unnumbered pages). |
| Catalogue number |
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| Subject terms | Hogs Chemical weapons Bioassay |
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