00000nam 2200000za 4500 9.847591 CaOODSP 20221107153457 cr ||||||||||| 171122s2018 onca o f000 0 eng d 9780660239675 9780660239682 CaOODSP eng n-cn--- NR16-176/2017E-PDF Salmonella vector (L-12259) [electronic resource]. [Ottawa] : National Research Council Canada, [2018] [1] p. : ill. Issued also in French under title: Vecteur de vaccin à base de salmonelle (L-12259). Caption title. "December 2017." “Promising approaches for delivering antigens and generating a protective response against cancers and infectious diseases currently employ existing vaccine strain bacteria or closely-related attenuated bacteria. Human clinical trials have shown excellent safety profiles with various recombinant vaccine strain bacteria, but generally poor efficacies for promoting immunity against the targeted diseases. Finding the right vaccine vector and antigen production system to rapidly induce an immune response while causing minimal toxicity has been challenging. To address this problem, the NRC has developed a recombinant attenuated Salmonella vaccine system capable of producing rapid cell-mediated immune protection against infectious diseases and cancers”--Highlights. Issued also in print format. Drug delivery systems Salmonella National Research Council Canada. Vecteur de vaccin à base de salmonelle (L-12259) (CaOODSP)9.847593 Salmonella vector (CaOODSP)9.847592 PDF 138 KB https://publications.gc.ca/collections/collection_2018/cnrc-nrc/NR16-176-2017-eng.pdf