Chemical, toxicological & genotoxicological characterization of sediments from the River Elbe, Germany / principal participants: Joachim Kurz and Rolf-Dieter Wilken ; and Salem S. Rao and John H. Carey. : En13-5/96-20E-PDF

"The occurrence of toxic chemicals in the sediments from river Elbe have been investigated in eight different locations from the Czech republic to the mouth of the Elbe. The method used is the bioassay-directed chemical analysis, which combines the use of chemical analysis and bioassays. The first step of the study is a sequential sediment extraction using the following solvents: water, hexane, methanol (pH=7), and methanol (pH=2). The fi-actions were examined for chemical analysis and for toxicity and genotoxicity testing. GC/MS with electron impact ionisation was used for the analysis of organic compounds. The acute toxicity was measured using the Microtox test (decreases in bioluminescence of the marine bacterium photobacterium phosphoreum). The methanol fractions (pH=7) were examined for mutagenicity using the MutaChromo-Plate assay. One fraction (OSA 68), which showed a mutagenic potential, was examined for genotoxic potential using the hepatic micronucleus assay in rainbow trout. The investigation showed a high toxicity in all fractions of the sediment from the river Bilina (OSA 68) and also a broad spectrum of organic pollutants. In the water fraction of this sediment the chemical responsible for the toxicity can be determined as Bisphenol A"--Abstract.

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