00000nam 2200000zi 4500 9.875989 CaOODSP 20240220151437 m o d f cr ||||||||||| 190708t20022002abc #o f000 0 eng d CaOODSP eng rda CaOODSP eng fre n-cn--- D68-3/170-2002E-PDF Chemical weapon agent studies in domestic swine : part 5 : comparative bioavailability of different HI-6 salt forms in the domestic pig / prepared by: Kinchyle Enterprises Inc. Comparative bioavailability of different HI-6 salt forms in the domestic pig Medicine Hat, Alberta, Canada : Defence Research and Development Canada = Recherche et développement pour la défense Canada, 2002. ©2002 1 online resource (ii, 37 pages, 2 unnumbered pages). text txt rdacontent computer c rdamedia online resource cr rdacarrier Contract report ; DRDC Suffield CR 2002-C170 "September 2002." "PWGSC Contract Number: W7702-99-R785." "A well-developed anesthetized domestic swine model has been utilized to study the following effect of chemical weapons (CW): 01 - Comparative bioavailability of different HI-6 salt forms in the domestic pig. The bioavailability of the dihydrochloride salt of HI-6a (currently utilized) was compared to that of the dimethanesulfonate salt (HI-6b). The latter is more water-soluble at low temperatures. The salts appear similarly clinically, biochemically or hematologically in the "equivalent" doses administered (HI-6 dihychloride = 500 mg, HI-6 dimethanesulfonate = 633 mg.) A notable exception might be the observation that the combination of pyridostigmine (PYR)/HI-6b increases airway resistance. Timed plasma and urine samples were collected for HPLC analysis"--Abstract, page i. Includes abstract in French. gccst Hogs gccst Chemical weapons gccst Bioassay Defence R&D Canada - Suffield. Contract report (Defence R&D Canada) DRDC Suffield CR 2002-C170. (CaOODSP)9.802312 PDF 6.37 MB https://publications.gc.ca/collections/collection_2019/rddc-drdc/D68-3-170-2002-eng.pdf