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| 02359nam 2200373zi 4500 |
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| 001 | 9.875989 |
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| 003 | CaOODSP |
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| 005 | 20240220151437 |
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| 006 | m o d f |
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| 007 | cr ||||||||||| |
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| 008 | 190708t20022002abc #o f000 0 eng d |
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| 040 | |aCaOODSP|beng|erda|cCaOODSP |
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| 041 | |aeng|bfre |
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| 043 | |an-cn--- |
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| 086 | 1 |aD68-3/170-2002E-PDF |
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| 245 | 00|aChemical weapon agent studies in domestic swine : |bpart 5 : comparative bioavailability of different HI-6 salt forms in the domestic pig / |cprepared by: Kinchyle Enterprises Inc. |
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| 246 | 10|aComparative bioavailability of different HI-6 salt forms in the domestic pig |
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| 264 | 1|aMedicine Hat, Alberta, Canada : |bDefence Research and Development Canada = Recherche et développement pour la défense Canada, |c2002. |
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| 264 | 4|c©2002 |
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| 300 | |a1 online resource (ii, 37 pages, 2 unnumbered pages). |
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| 336 | |atext|btxt|2rdacontent |
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| 337 | |acomputer|bc|2rdamedia |
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| 338 | |aonline resource|bcr|2rdacarrier |
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| 490 | 1 |aContract report ; |vDRDC Suffield CR 2002-C170 |
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| 500 | |a"September 2002." |
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| 500 | |a"PWGSC Contract Number: W7702-99-R785." |
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| 520 | 3 |a"A well-developed anesthetized domestic swine model has been utilized to study the following effect of chemical weapons (CW): 01 - Comparative bioavailability of different HI-6 salt forms in the domestic pig. The bioavailability of the dihydrochloride salt of HI-6a (currently utilized) was compared to that of the dimethanesulfonate salt (HI-6b). The latter is more water-soluble at low temperatures. The salts appear similarly clinically, biochemically or hematologically in the "equivalent" doses administered (HI-6 dihychloride = 500 mg, HI-6 dimethanesulfonate = 633 mg.) A notable exception might be the observation that the combination of pyridostigmine (PYR)/HI-6b increases airway resistance. Timed plasma and urine samples were collected for HPLC analysis"--Abstract, page i. |
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| 546 | |aIncludes abstract in French. |
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| 692 | 07|2gccst|aHogs |
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| 692 | 07|2gccst|aChemical weapons |
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| 692 | 07|2gccst|aBioassay |
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| 710 | 1 |aDefence R&D Canada - Suffield. |
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| 830 | #0|aContract report (Defence R&D Canada)|vDRDC Suffield CR 2002-C170.|w(CaOODSP)9.802312 |
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| 856 | 40|qPDF|s6.37 MB|uhttps://publications.gc.ca/collections/collection_2019/rddc-drdc/D68-3-170-2002-eng.pdf |
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