Immunoassays and other biologically based screening methods for dioxins, furans and PCBs / J. Sherry. : En13-5/93-83E-PDF

"An array of screening tests have been developed for the detection of dioxins and dioxin like molecules such as furans and polychlorinated biphenyls (PCBs). The tests may be divided into two categories: ligand binding assays and bioassays. The ligand binding assays include immunoassays and receptor binding assays. The bioassays include in-vitro and in-situ MFO induction assays (mixed function oxidase) and bioassays that are based on toxic responses. Key methods in each group are described. The screening tests can be used to lower overall analytical costs and can also provide useful information about the toxic potency and potential impact on the biota of the planar halogenated hydrocarbons. Many of the bioassays have broad specificity which makes them responsive to a variety of planar molecules that can mimic 2,3,7,8-T₄CDD. On the other hand the bioassays tend to respond to a sample in proportion to its biological potency. The screening tests can be used to increase our knowledge of the distribution and importance of dioxin-like molecules in the environment"--Abstract.

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