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Identification of a novel virulence factor of Burkholderia pseudomallei and B. mallei, a protective vaccine antigen against melioidosis / Chad W. Stratilo, Rick Swayze, Scott Jager, DRDC - Suffield Research...: D68-2/189-2018E-PDF

"Burkholderia pseudomallei is the causative agent of melioidosis, a severe systemic, potentially life-threatening disease with many possible manifestations in humans. This pathogen expresses a large number of virulence factors, with many found on islands of pathogenesis. Significant efforts have been invested into vaccine development; however none have offered complete protection. A unique and conserved protein of B. pseudomallei and B. mallei has been identified as the exoprotein of a two-partner secretion pathway. This exoprotein, when expressed in a recombinant form effected the formation of actin tails in macrophage cell culture, suggesting a role in intracellular spread and a possible role in virulence. A truncated recombinant form of this protein conferred protection against B. pseudomallei and B. mallei challenge in mice when used as a vaccine candidate"--Abstract, page i.

Permanent link to this Catalogue record:
publications.gc.ca/pub?id=9.871273&sl=0

Publication information
Department/Agency
  • Defence R&D Canada - Suffield.
TitleIdentification of a novel virulence factor of Burkholderia pseudomallei and B. mallei, a protective vaccine antigen against melioidosis / Chad W. Stratilo, Rick Swayze, Scott Jager, DRDC - Suffield Research Centre.
Series title
  • Scientific report ; DRDC-RDDC-2018-R189
Publication typeMonograph - View Master Record
Language[English]
FormatDigital text
Electronic document
Note(s)
  • Cover title.
  • "Can unclassified."
  • "October 2018."
  • Includes bibliographical references.
  • Includes abstract in French.
Publishing information
  • Medicine Hat, Alberta : Defence Research and Development Canada = Recherche et développement pour la défense Canada, 2018.
  • ©2018
Author / Contributor
  • Stratilo, Chad W., author.
  • Swayze, Rick, author.
  • Jager, Scott, author.
Description1 online resource (vi, 19 pages, 2 unnumbered pages) : illustrations.
Catalogue number
  • D68-2/189-2018E-PDF
Subject terms
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