Identification of a novel virulence factor of Burkholderia pseudomallei and B. mallei, a protective vaccine antigen against melioidosis / Chad W. Stratilo, Rick Swayze, Scott Jager, DRDC - Suffield Research...: D68-2/189-2018E-PDF
"Burkholderia pseudomallei is the causative agent of melioidosis, a severe systemic, potentially life-threatening disease with many possible manifestations in humans. This pathogen expresses a large number of virulence factors, with many found on islands of pathogenesis. Significant efforts have been invested into vaccine development; however none have offered complete protection. A unique and conserved protein of B. pseudomallei and B. mallei has been identified as the exoprotein of a two-partner secretion pathway. This exoprotein, when expressed in a recombinant form effected the formation of actin tails in macrophage cell culture, suggesting a role in intracellular spread and a possible role in virulence. A truncated recombinant form of this protein conferred protection against B. pseudomallei and B. mallei challenge in mice when used as a vaccine candidate"--Abstract, page i.
Permanent link to this Catalogue record:
publications.gc.ca/pub?id=9.871273&sl=0
| Department/Agency | Canada. Defence R&D Canada. Suffield Research Centre. |
|---|---|
| Title | Identification of a novel virulence factor of Burkholderia pseudomallei and B. mallei, a protective vaccine antigen against melioidosis / Chad W. Stratilo, Rick Swayze, Scott Jager, DRDC - Suffield Research Centre. |
| Series title | Scientific report ; DRDC-RDDC-2018-R189 |
| Publication type | Series - View Master Record |
| Language | [English] |
| Format | Electronic |
| Electronic document | |
| Note(s) | Cover title. "Can unclassified." "October 2018." Includes bibliographical references. Includes abstract in French. |
| Publishing information | Medicine Hat, Alberta : Defence Research and Development Canada = Recherche et développement pour la défense Canada, 2018. ©2018 |
| Author / Contributor | Stratilo, Chad W., author. Swayze, Rick, author. Jager, Scott, author. |
| Description | 1 online resource (vi, 19 pages, 2 unnumbered pages) : illustrations. |
| Catalogue number |
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| Subject terms | Immunization |
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